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yhaM [2019-09-06 08:34:58]
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yhaM [2019-09-06 08:34:58]

RNase, 3 5 exoribonuclease
locus
BSU_09930
pI
5.85
mw
35.53 kDa
protein length
314 aa Sequence Blast
gene length
945 bp Sequence Blast
function
RNA degradation
product
RNase YhaM
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.1|Exoribonucleases]

    • Gene

    Coordinates
    1,069,042 1,069,986

    The protein

    Catalyzed reaction/ biological activity

  • 3'-5' exoribonuclease

    • Protein family

  • YhaM family (single member, according to UniProt)

    • [SW|Domains]

  • [SW|HD domain] (aa 156 ... 297) (according to the Interpro database)

    • [SW|Localization]

  • cytoplasm (Homogeneous) [Pubmed|16479537]

    • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]

    • Expression and Regulation

    Operons

    genes
    [gene|3E27C881BB3DE3FD55B7AD21B8771A859D80786F|yhaO]-[gene|709C4D0AE9C78C9A367F37B9C3B37D2516850D7C|sbcE]-[gene|6D585EB5E56A1E5C1C31680D960043BA08C817E2|yhaM]
    description
    [Pubmed|16267290]

    regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]

    • regulation

  • induced by DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]) [Pubmed|16267290]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-B499 (yhaM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1498 NBRP B. subtilis, Japan]
  • BKE09930 ([gene|6D585EB5E56A1E5C1C31680D960043BA08C817E2|yhaM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE09930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTATTAAAGCTCCCTC, downstream forward: _UP4_TAACTTAAAAAGGACTGATG
  • BKK09930 ([gene|6D585EB5E56A1E5C1C31680D960043BA08C817E2|yhaM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK09930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTATTAAAGCTCCCTC, downstream forward: _UP4_TAACTTAAAAAGGACTGATG

    • labs

  • [SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers Laboratories and Programs/Bechhofer Laboratory?citype=Physician&ciid=Bechhofer David H 1255565 Homepage]

    • References

    Reviews

  • 31464530

    • Original Publications

  • 19732150,12399495,19553197,16267290,16479537,17981983,15805522,19880604